In the USA, the standard household voltage is 110V, so directly plugging a 220V appliance into a regular socket will not work and may damage the appliance. However, you can use a step-up transformer or voltage converter to safely run a 220V appliance on a 110V power supply. Additionally, some high-power outlets, like those for dryers or ovens, provide 220V in the USA, but these are specific and require proper knowledge before use. Always check the appliance’s voltage requirements and use the appropriate conversion tools.